初次全膝关节置换术后创伤后关节炎与骨关节炎的结局：一项匹配队列研究方案。
The outcomes of post-traumatic arthritis vs osteoarthritis following primary total knee arthroplasty: A protocol of matched cohort study.
作者信息
Li Jin-Quan, Sun Ze-Gan, Huang Qing-Song, Yao Xiao-Dong
机构信息
Department of Orthopedics, 900TH Hospital of Joint Logistics Support Force, FuZhou, China.
出版信息
Medicine (Baltimore). 2020 May;99(19):e20077. doi: 10.1097/MD.0000000000020077.
BACKGROUND
Total knee arthroplasty (TKA) for treatment of end-stage post-traumatic arthritis (PTA) has specific technical difficulties and complications. The aim of this study was to examine the outcome of TKA after PTA and to compare it with a cohort osteoarthritis (OA).
METHODS
A retrospective review of patients undergoing primary TKA at a single university hospital from 2013 to 2016 was performed. A minimum follow-up of 4 years was required. Patients in the study group were matched 1:2 with patients in the cohort group based on the following criteria: age at time of TKA (±3 years), body mass index (±3 points), sex, and American Society of Anesthesiologists score (±1 point). Outcome measures included surgical time, intraoperative complications, Oxford Knee Score, range of motion, postoperative complications, and revision.
RESULTS
This clinical trial is expected to determine whether PTA is associated with increased risks of complications and revision or reduced functional outcomes following TKA.
TRIAL REGISTRATION
This study protocol was registered in Research Registry (researchregistry5455).
背景
全膝关节置换术（TKA）用于治疗创伤后终末期关节炎（PTA）存在特定的技术难题和并发症。本研究旨在探讨PTA后TKA的疗效，并与骨关节炎（OA）队列进行比较。
方法
对2013年至2016年在一家大学医院接受初次TKA的患者进行回顾性研究。要求至少随访4年。研究组患者根据以下标准与队列组患者按1:2进行匹配：TKA时的年龄（±3岁）、体重指数（±3分）、性别和美国麻醉医师协会评分（±1分）。观察指标包括手术时间、术中并发症、牛津膝关节评分、活动范围、术后并发症和翻修情况。
结果
本临床试验有望确定PTA是否与TKA后并发症和翻修风险增加或功能结局降低相关。
试验注册
本研究方案已在研究注册库（researchregistry5455）注册。
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