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接受腹腔镜可调节胃束带手术的肥胖患者发生静脉血栓栓塞的风险、依诺肝素的使用及临床结局:一项回顾性研究

Risk of venous thromboembolism, use of enoxaparin and clinical outcomes in obese patients undergoing laparoscopic adjustable gastric band surgery: A retrospective study.

作者信息

Hussain Zahid, Peterson Gregory M, Mirkazemi Corinne, Curtain Colin, Zaidi Syed Tabish R

机构信息

School of Pharmacy and Pharmacology, Faculty of Health, University of Tasmania, Sandy Bay, TAS.

Discipline of Pharmacy, Faculty of Health, University of Canberra, Bruce, ACT, Australia.

出版信息

Medicine (Baltimore). 2020 May;99(19):e20174. doi: 10.1097/MD.0000000000020174.

Abstract

There is a lack of clear guidance for the prophylactic use of anticoagulants for patients undergoing laparoscopic adjustable gastric banding (LAGB) surgery.This study aimed to evaluate the risk of venous thromboembolism (VTE), prophylactic use of enoxaparin and clinical outcomes in patients undergoing primary and revisional LAGB procedures.A retrospective study evaluated the prophylactic use of enoxaparin in adult patients who underwent primary and revisional (band and port) LAGB procedures. The incidence of VTE and major bleeding was investigated during a 90-day follow-up period. Descriptive and inferential statistics were used for data analysis.We included 112 and 100 patients who had undergone primary and revisional (24 band procedures and 76 port procedures) LAGB surgery, respectively. The majority of patients (97%) had a mild risk of VTE development using a post-discharge VTE risk calculator tool published from the Cleveland Clinic. All primary procedure patients received prophylactic enoxaparin, compared to 79% and 20% of revisional patients who underwent band and port procedures, respectively (P < .001). The overall VTE incidence was 0.9%, with no significant difference between patients who did or did not receive chemoprophylaxis (0.7% and 1.5%, respectively; P = .58). No major bleeding events were observed.Chemoprophylaxis may not be required in all patients undergoing low-risk LAGB surgery unless there are additional risk factors, such as the presence of super-super-morbid obesity or concomitant hormone replacement therapy. More studies are needed on the prophylactic use and dosing of enoxaparin in patients undergoing LAGB procedures to provide high-level evidence.

摘要

对于接受腹腔镜可调节胃束带术(LAGB)的患者,在预防性使用抗凝剂方面缺乏明确的指导。本研究旨在评估接受初次和翻修LAGB手术患者的静脉血栓栓塞(VTE)风险、依诺肝素的预防性使用情况及临床结局。一项回顾性研究评估了接受初次和翻修(束带和端口)LAGB手术的成年患者中依诺肝素的预防性使用情况。在90天的随访期内调查VTE和大出血的发生率。采用描述性和推断性统计进行数据分析。我们分别纳入了112例和100例接受初次和翻修(24例束带手术和76例端口手术)LAGB手术的患者。使用克利夫兰诊所发布的出院后VTE风险计算器工具,大多数患者(97%)发生VTE的风险较低。所有初次手术患者均接受了预防性依诺肝素治疗,相比之下,接受束带和端口手术的翻修患者分别为79%和20%(P<0.001)。总体VTE发生率为0.9%,接受或未接受化学预防的患者之间无显著差异(分别为0.7%和1.5%;P=0.58)。未观察到大出血事件。除非存在其他风险因素,如超级病态肥胖或同时进行激素替代治疗,否则并非所有接受低风险LAGB手术的患者都可能需要化学预防。需要更多关于接受LAGB手术患者依诺肝素预防性使用和剂量的研究,以提供高级别证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d6e/7220426/f03d3c9edaa1/medi-99-e20174-g001.jpg

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