Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China; School of Data Science, University of Science and Technology of China, Hefei, 230026, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, China.
Mol Aspects Med. 2020 Dec;76:100859. doi: 10.1016/j.mam.2020.100859. Epub 2020 May 6.
NOD-like receptor family pyrin domain containing 6 (NLRP6) is a novel NLR family member, that shows high expression in the intestine and liver (in contrast to NLRP3 in myeloid cells), to regulate inflammation and host defense against microbes. NLRP6 is reported to involved in inflammasome activation, regulation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling, antiviral interferon (IFN) signaling, mucus secretion, and antimicrobial peptide (AMP) production. Here, we discuss the recent findings as well as debates regarding: how NLRP6 is induced ("signal I″) and activated ("signal II"); its roles in intestinal cells and immune cells; how NLRP6 and NLRP9 coordinate to regulate the anti-viral immune response in the intestine; potential targeting of NLRP6 in human diseases.
NOD 样受体家族包含吡咯烷域 6（NLRP6）是一种新型的 NLR 家族成员，在肠道和肝脏中高表达（与髓样细胞中的 NLRP3 相反），以调节炎症和宿主对微生物的防御。据报道，NLRP6 参与炎症小体的激活、核因子-κB（NF-κB）和丝裂原活化蛋白激酶（MAPK）信号转导、抗病毒干扰素（IFN）信号转导、粘液分泌和抗菌肽（AMP）的产生。在这里，我们讨论了最近的发现以及关于以下方面的争论：NLRP6 是如何被诱导（“信号 I”）和激活（“信号 II”）的；它在肠道细胞和免疫细胞中的作用；NLRP6 和 NLRP9 如何协调调节肠道中的抗病毒免疫反应；NLRP6 在人类疾病中的潜在靶向治疗。
