疑似子痫前期 DELFIA Xpress PlGF 1-2-3 检测的纳入阈值。
Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia.
机构信息
Women's Health Academic Centre, St Thomas' Hospital, King's College London, United Kingdom.
出版信息
Pregnancy Hypertens. 2020 Jul;21:35-37. doi: 10.1016/j.preghy.2020.04.005. Epub 2020 Apr 22.
We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks' gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsiarequiring delivery within 14 days (specificity 95.0% (95% CI 91.7-97.2%), positive predictive value50 (95% CI 30.6-69.4%), positive likelihood ratio 10.7 (5.8-20).
我们旨在为 DELFIA Xpress 胎盘生长因子 (PlGF) 1-2-3 检测建立一个阳性预测值。通过三种不同的基于 PlGF 的检测方法对 305 名在 35 周妊娠前出现疑似先兆子痫的 EDTA 血浆样本进行了分析：PlGF 1-2-3 检测（PerkinElmer）；Triage PlGF 检测（Quidel）；Elecsys 免疫分析法 sFlt-1/PlGF 比值（罗氏）。用与 Quidel 和罗氏检测等效的特异性创建的 PlGF 1-2-3 检测的阳性预测值为 50pg/ml。这可作为在 14 天内需要分娩的早产先兆子痫的阳性预测值（特异性 95.0%（95%CI91.7-97.2%），阳性预测值 50（95%CI30.6-69.4%），阳性似然比 10.7（5.8-20））。
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