无症状中国成年人血红蛋白水平与结直肠息肉的关联
Association between Hemoglobin Levels and Colorectal Polyps in Asymptomatic Chinese Adults.
作者信息
Shen Chao, Shi Xiaoying, Al-Ashoor Maram, Xu Chengfu
机构信息
Health Management Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
出版信息
Gastroenterol Res Pract. 2020 Jan 18;2020:3808163. doi: 10.1155/2020/3808163. eCollection 2020.
METHODS
A cross-sectional analysis was performed among 1633 asymptomatic adults who underwent colonoscopy examinations during routine health check-ups at the First Affiliated Hospital, College of Medicine, Zhejiang University, between 2015 and 2018.
RESULTS
A total of 449 (27.50%) participants were diagnosed with colorectal polyps, and those with colorectal polyps had significantly higher hemoglobin levels than did those without colorectal polyps. Hemoglobin levels were positively associated with the prevalence of colorectal polyps, with rates of 16.43%, 26.20%, 32.17%, and 35.87% among participants with hemoglobin levels in the first, second, third, and fourth quartiles, respectively ( for trend < 0.001). Stepwise multiple regression analysis showed that elevated hemoglobin levels independently increased the risk of colorectal polyps (odd ratio = 1.017; 95% confidence interval: 1.008-1.026).
CONCLUSION
Elevated hemoglobin levels were significantly and independently associated with the prevalence and risk of colorectal polyps in asymptomatic adults.
方法
对2015年至2018年间在浙江大学医学院附属第一医院进行常规健康检查时接受结肠镜检查的1633名无症状成年人进行横断面分析。
结果
共有449名（27.50%）参与者被诊断为结直肠息肉，结直肠息肉患者的血红蛋白水平显著高于无结直肠息肉者。血红蛋白水平与结直肠息肉患病率呈正相关，血红蛋白水平处于第一、第二、第三和第四四分位数的参与者中，患病率分别为16.43%、26.20%、32.17%和35.87%（趋势检验P<0.001）。逐步多元回归分析显示，血红蛋白水平升高独立增加结直肠息肉风险（比值比=1.017；95%置信区间：1.008 - 1.026）。
结论
血红蛋白水平升高与无症状成年人结直肠息肉的患病率和风险显著且独立相关。
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