Samson Guerric P B, Legler Daniel F
Biotechnology Institute Thurgau at the University of Konstanz, Kreuzlingen, Switzerland.
Faculty of Biology, University of Konstanz, Konstanz, Germany.
Front Cell Dev Biol. 2020 Apr 28;8:285. doi: 10.3389/fcell.2020.00285. eCollection 2020.
Leukocyte migration across vessels into and within peripheral and lymphoid tissues is essential for host defense against invading pathogens. Leukocytes are specialized in sensing a variety of guidance cues and to integrate environmental stimuli to navigate in a timely and spatially controlled manner. These extracellular signals must be transmitted across the leukocyte's plasma membrane in a way that intracellular signaling cascades enable directional cell movement. Therefore, the composition of the membrane in concert with proteins that influence the compartmentalization of the plasma membrane or contribute to delineate intracellular signaling molecules are key in controlling leukocyte navigation. This becomes evident by the fact that mislocalization of membrane proteins is known to deleteriously affect cellular functions that may cause diseases. In this review we summarize recent advances made in the understanding of how membrane cholesterol levels modulate chemokine receptor signaling and hence leukocyte trafficking. Moreover, we provide an overview on the role of membrane scaffold proteins, particularly tetraspanins, flotillins/reggies, and caveolins in controlling leukocyte migration both and .
白细胞穿过血管迁移到外周组织和淋巴组织中并在其中移动，对于宿主抵御入侵病原体至关重要。白细胞专门用于感知各种引导信号，并整合环境刺激，以便以时间和空间控制的方式导航。这些细胞外信号必须以一种细胞内信号级联能够实现细胞定向移动的方式穿过白细胞的质膜。因此，膜的组成与影响质膜区室化或有助于描绘细胞内信号分子的蛋白质协同作用，对于控制白细胞导航至关重要。膜蛋白的错误定位会有害地影响可能导致疾病的细胞功能，这一事实就证明了这一点。在本综述中，我们总结了在理解膜胆固醇水平如何调节趋化因子受体信号传导从而影响白细胞运输方面取得的最新进展。此外，我们概述了膜支架蛋白，特别是四跨膜蛋白、浮舰蛋白/瑞吉蛋白和小窝蛋白在控制白细胞迁移方面的作用。
