Brattström A, De Jong W, De Wied D
Rudolf Magnus Institute of Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.
J Hypertens Suppl. 1988 Dec;6(4):S521-4. doi: 10.1097/00004872-198812040-00164.
Bilateral micro-injections of arginine vasopressin into the nucleus tractus solitarii caused a dose-dependent (1-100 pg) decrease in blood pressure and heart rate in anaesthetized rats. Higher doses (1-20 ng) caused an increase in both parameters. Subcutaneous injection of an antagonist [d(CH2)5Tyr(Me)-arginine vasopressin] failed to block these effects. Micro-injections of the antagonist (0:1-100 pg) into the nucleus tractus solitarii decreased blood pressure and the heart rate similarly to arginine vasopressin. The effect of the antagonist disappeared after about 30 min. At that time administration of arginine vasopressin into the nucleus tractus solitarii was ineffective in inducing changes in blood pressure and the heart rate. When a low-dose (0.1 or 1 pg) antagonist was used the effect of 100 pg arginine vasopressin was partially inhibited. We conclude that administration of arginine vasopressin into the nucleus tractus solitarii is effective at low doses, and may be involved in inhibitory cardiovascular control at the level of nucleus tractus solitarii.
在麻醉大鼠中，向孤束核双侧微量注射精氨酸加压素会导致剂量依赖性（1 - 100皮克）的血压和心率下降。更高剂量（1 - 20纳克）则会使这两个参数升高。皮下注射拮抗剂[d(CH2)5Tyr(Me)-精氨酸加压素]未能阻断这些效应。向孤束核微量注射拮抗剂（0.1 - 100皮克）会使血压和心率下降，与精氨酸加压素的作用相似。拮抗剂的作用在约30分钟后消失。此时向孤束核注射精氨酸加压素对血压和心率的改变无效。当使用低剂量（0.1或1皮克）拮抗剂时，100皮克精氨酸加压素的作用会被部分抑制。我们得出结论，向孤束核注射低剂量精氨酸加压素是有效的，并且可能参与孤束核水平的抑制性心血管控制。
