雌激素受体信号转导调节前列腺癌中的长非编码 RNA。

Signaling through estrogen receptors modulates long non-coding RNAs in prostate cancer.

机构信息

Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168, Roma, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168, Roma, Italy.

出版信息

Mol Cell Endocrinol. 2020 Jul 1;511:110864. doi: 10.1016/j.mce.2020.110864. Epub 2020 May 13.

DOI:10.1016/j.mce.2020.110864

PMID:32413384

Abstract

Prostate cancer (PCa) is a sex-steroid hormone-dependent cancer in which estrogens play a critical role in both initiation and progression. Recently, several long non-coding RNAs (lncRNAs) have been associated with PCa and are supposedly playing a pivotal role in the biology and progression of this type of cancer. In this review, we focused on some lncRNAs that are known for their androgen and estrogen transcriptional responsiveness in PCa. Specifically, we summarized recent pieces of evidence about lncRNAs NEAT1, H19, MALAT1, and HOTAIR, in estrogen signaling, emphasizing their role in PCa progression and the acquisition of a castration-resistant phenotype. Here, the reader will find information about lncRNAs present in estrogen-dependent transcriptional complexes. The potential role of lncRNA/estrogen signaling as a novel pathway for PCa treatment will be discussed.

摘要

前列腺癌（PCa）是一种依赖性激素的癌症，其中雌激素在其发生和发展中起着关键作用。最近，一些长链非编码 RNA（lncRNAs）与 PCa 相关，并被认为在这种癌症的生物学和进展中起着关键作用。在这篇综述中，我们集中讨论了一些已知在前列腺癌中具有雄激素和雌激素转录反应性的 lncRNAs。具体来说，我们总结了最近关于 lncRNAs NEAT1、H19、MALAT1 和 HOTAIR 在雌激素信号中的作用的证据，强调了它们在前列腺癌进展和获得去势抵抗表型中的作用。在这里，读者将找到关于存在于雌激素依赖性转录复合物中的 lncRNAs 的信息。lncRNA/雌激素信号作为一种治疗前列腺癌的新途径的潜在作用将被讨论。