Biomedicine Unit, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, MEX C.P. 54090, Mexico.
Department of Immunology, Institute of Biomedical Research, Universidad Nacional Autónoma de México (UNAM), Mexico City C.P. 04510, Mexico.
Cytokine. 2020 Sep;133:155121. doi: 10.1016/j.cyto.2020.155121. Epub 2020 May 11.
Human macrophage migration inhibition factor (MIF) is a protein with cytokine and chemokine properties that regulates a diverse range of physiological functions related to innate immunity and inflammation. Most research has focused on the role of MIF in different inflammatory diseases. D-dopachrome tautomerase (DDT), a different molecule with structural similarities to MIF, which shares receptors and biological functions, has recently been reported, but little is known about its roles and mechanisms. In this review, we sought to understand the similarities and differences between these molecules by summarizing what is known about their different structures, receptors and mechanisms regulating their expression and biological activities with an emphasis on immunological aspects.
人类巨噬细胞移动抑制因子（MIF）是一种具有细胞因子和趋化因子特性的蛋白质，调节与先天免疫和炎症相关的多种生理功能。大多数研究都集中在 MIF 在不同炎症性疾病中的作用。最近报道了 D-多巴色素互变异构酶（DDT），这是一种与 MIF 具有结构相似性的不同分子，它具有共同的受体和生物学功能，但关于其作用和机制知之甚少。在这篇综述中，我们通过总结已知的关于它们不同结构、受体和调节其表达和生物学活性的机制，重点关注免疫学方面，试图了解这些分子之间的相似之处和不同之处。
