Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA.
Center for Integrated Fungal Research, North Carolina State University, Raleigh, NC, USA.
Vet Ophthalmol. 2020 Sep;23(5):918-922. doi: 10.1111/vop.12774. Epub 2020 May 16.
To determine minimum inhibitory concentrations (MICs) of four fungal species isolated from horses presented with equine fungal keratitis (EFK) in the southeastern United States to previously untested azole, echinocandin, and carboxamide antifungal drugs.
In vitro assays were performed to determine the susceptibility of Aspergillus flavus, A. fumigatus, Fusarium falciforme, and F. keratoplasticum to five antifungal drugs representing three modes of action.
Luliconazole exhibited increased growth inhibition against both Aspergillus and Fusarium compared to commonly used, standard antifungal drugs. MIC values for luliconazole at 0.001-0.002 µg/mL were at least 25-fold lower than all other antifungal drugs tested, including voriconazole.
The increased antifungal activity of luliconazole observed in this study warrants further investigation for its potential as an antifungal drug for equine fungal keratitis.
测定从美国东南部患有马真菌角膜炎（EFK）的马中分离出的四种真菌对以前未测试过的唑类、棘白菌素和羧酰胺类抗真菌药物的最小抑菌浓度（MICs）。
进行体外测定以确定黄曲霉、烟曲霉、镰孢弯孢霉和 F. keratoplasticum 对代表三种作用模式的五种抗真菌药物的敏感性。
与常用的标准抗真菌药物相比，卢立康唑对曲霉菌和镰刀菌的生长抑制作用更强。卢立康唑的 MIC 值为 0.001-0.002 µg/mL，至少比所有其他测试的抗真菌药物低 25 倍，包括伏立康唑。
本研究中观察到卢立康唑的抗真菌活性增加，值得进一步研究其作为马真菌角膜炎抗真菌药物的潜力。
Zotero 插件