Division of Cardiology, Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA.
Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA.
Eur J Intern Med. 2020 Oct;80:24-28. doi: 10.1016/j.ejim.2020.04.048. Epub 2020 May 14.
Cannabis (marijuana) use and depression are known to be strongly interconnected. However, amid alarming rates of mental health problems in the United States young population, the risk of arrhythmia among young cannabis users with comorbid depression has never been studied.
In-hospital encounters of arrhythmia were identified among young cannabis users (18-39 years) with or without depression using the National Inpatient Sample (2007-2014) databases and apposite ICD-9 codes. Baseline characteristics and trends in prevalence of arrhythmia were evaluated among inpatient young cannabis users with or without depression. A multivariable regression was performed after adjusting for baseline demographics, comorbidities and parallel history of substance abuse.
Of 2,011,598 young cannabis users (59.6% male) admitted from 2007-2014, 190,146 (9.5%) of patients had comorbid depression, of which 6.9% of patients experienced arrhythmias with atrial fibrillation being most common. Cannabis users with depression were more likely older, white, females and frequently hospitalized in Midwest and rural hospitals. We observed a steadily rising trend in prevalence of arrhythmia in both groups, but a more rapid rise in cannabis users with depression (4.9% in 2007 to 8.5% in 2014 vs. 3.7% in 2007 to 5.7% in 2014). Correspondingly, young depressed cannabis users had higher odds of arrhythmia compared to non-depressed even after controlling for demographics and comorbidities (OR: 1.41, 95% CI: 1.38-1.44, p<0.001).
Rampant recreational use of marijuana may increase the risk of arrhythmia by 40% in young cannabis users with depression as compared to non-depressed.
大麻（ marijuana ）的使用与抑郁之间存在着紧密的关联。然而，在美国年轻人中，精神健康问题的发生率令人担忧，目前尚未研究过患有共病抑郁症的年轻大麻使用者发生心律失常的风险。
使用国家住院患者样本（ 2007-2014 年）数据库和适当的 ICD-9 编码，确定患有或不患有抑郁症的年轻大麻使用者（ 18-39 岁）的心律失常住院病例。评估患有或不患有抑郁症的年轻大麻使用者的心律失常住院病例的基线特征和患病率趋势。在调整基线人口统计学、合并症和物质滥用平行史后，进行多变量回归。
在 2007-2014 年期间， 2011598 名年轻大麻使用者（ 59.6%为男性）中，有 190146 名（ 9.5%）患者患有共病抑郁症，其中 6.9%的患者出现心律失常，最常见的是心房颤动。患有抑郁症的大麻使用者年龄更大、更可能为白人、女性，并且经常在中西部和农村医院住院治疗。我们观察到两个组中心律失常的患病率都呈稳步上升趋势，但患有抑郁症的大麻使用者的上升速度更快（ 2007 年为 4.9%， 2014 年为 8.5%，而 2007 年为 3.7%， 2014 年为 5.7%）。相应地，即使在控制了人口统计学和合并症后，与非抑郁组相比，年轻抑郁型大麻使用者发生心律失常的几率更高（比值比： 1.41，95%置信区间： 1.38-1.44， p<0.001）。
与非抑郁者相比，患有共病抑郁症的年轻大麻使用者中，大麻的消遣性使用可能会使心律失常的风险增加 40%。
