Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Twin Res Hum Genet. 2020 Apr;23(2):84-86. doi: 10.1017/thg.2020.37. Epub 2020 May 19.
The extended twin model is a unique design in the genetic epidemiology toolbox that allows to simultaneously estimate multiple causes of variation such as genetic and cultural transmission, genotype-environment covariance and assortative mating, among others. Nick Martin has played a key role in the conception of the model, the collection of substantially large data sets to test the model, the application of the model to a range of phenotypes, the publication of the results including cross-cultural comparisons, the evaluation of bias and power of the design and the further elaborations of the model, such as the children-of-twins design.
扩展双胞胎模型是遗传流行病学工具包中的一种独特设计,它可以同时估计多种变异原因,如遗传和文化传播、基因型-环境协方差和同型交配等。尼克·马丁在模型的构思、收集大量数据集以检验模型、将模型应用于一系列表型、发表结果(包括跨文化比较)、评估设计的偏差和功效以及进一步阐述模型方面发挥了关键作用,例如双胞胎子女设计。