College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China.
Org Biomol Chem. 2020 Jun 10;18(22):4257-4266. doi: 10.1039/d0ob00778a.
An efficient sulfide-catalyzed [2 + 1] annulation of para-quinone methides (p-QMs) with diverse bromides has been achieved. This catalytic strategy provides an efficient and straightforward protocol for accessing a variety of spiro-cyclopropanyl-cyclohexadienone compounds in good to excellent yields (64% to 96% yields) with outstanding diastereoselectivities (>20 : 1 dr), displaying good functional group tolerance as well as gram-scale capacity.
一种高效的硫代化合物催化的 para-醌甲醚（p-QMs）与各种溴化物的[2 + 1]环化反应已经实现。这种催化策略为获得各种螺环丙基环己二烯酮化合物提供了一种高效、直接的方法，产率良好至优秀（64%至96%），具有出色的非对映选择性（>20：1 dr），显示出良好的官能团耐受性以及克级规模的产率。
