Emerg Infect Dis. 2020 Jun;26(6):1212-1220. doi: 10.3201/eid2606.191517.
The worldwide spread of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) isolates was reported to be caused by dissemination of 1 clonal complex (i.e., clonal group [CG] 258, which includes sequence types [STs] 258 and 512). We conducted whole-genome sequencing and epidemiologic analysis of all KPC-Kp isolates in France in 2018 and found that new successful high-risk clones of ST147, ST307, ST231, and ST383 are now the main drivers of bla genes. The bla genes were mostly carried by Tn4401a and Tn4401d structures and a new non-Tn4401 element. Our epidemiologic investigations showed that the emergence of these non-CG258 KPC-Kp isolates in France was linked to dissemination of these clones from Portugal. Thus, KPC-Kp epidemiology has changed in Europe, at least in several non-KPC-endemic countries of western Europe, such as France and Portugal, where CG258 is not the most prevalent clone.
据报道，全球范围内产碳青霉烯酶肺炎克雷伯菌（KPC-Kp）分离株的传播是由 1 个克隆群（即克隆组[CG]258，包括序列类型[ST]258 和 512）的传播引起的。我们对 2018 年法国所有 KPC-Kp 分离株进行了全基因组测序和流行病学分析，发现新的成功的高风险 ST147、ST307、ST231 和 ST383 克隆是 bla 基因的主要驱动因素。bla 基因主要由 Tn4401a 和 Tn4401d 结构和一个新的非 Tn4401 元件携带。我们的流行病学调查显示，这些非 CG258 KPC-Kp 分离株在法国的出现与这些克隆从葡萄牙传播有关。因此，KPC-Kp 的流行病学在欧洲已经发生了变化，至少在法国和葡萄牙等西欧几个非 KPC 流行的国家是如此，在这些国家，CG258 并不是最流行的克隆。
