Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, Bandar Sunway, Kuala Lumpur, Selangor 47500, Malaysia.
Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.
Int J Mol Sci. 2020 May 20;21(10):3599. doi: 10.3390/ijms21103599.
There has been a great interest in myeloid-derived suppressor cells (MDSCs) due to their biological functions in tumor-mediated immune escape by suppressing antitumor immune responses. These cells arise from altered myelopoiesis in response to the tumor-derived factors. The most recognized function of MDSCs is suppressing anti-tumor immune responses by impairing T cell functions, and these cells are the most important players in cancer dissemination and metastasis. Therefore, understanding the factors and the mechanism of MDSC differentiation, expansion, and recruitment into the tumor microenvironment can lead to its control. However, most of the studies only defined MDSCs with no further characterization of granulocytic and monocytic subsets. In this review, we discuss the mechanisms by which specific MDSC subsets contribute to cancers. A better understanding of MDSC subset development and the specific molecular mechanism is needed to identify treatment targets. The understanding of the specific molecular mechanisms responsible for MDSC accumulation would enable more precise therapeutic targeting of these cells.
由于髓系来源的抑制性细胞（MDSCs）在肿瘤介导的免疫逃逸中通过抑制抗肿瘤免疫反应方面具有生物学功能，因此人们对其产生了极大的兴趣。这些细胞源自对肿瘤衍生因子的反应而改变的髓系造血。MDSCs 最被认可的功能是通过损害 T 细胞功能来抑制抗肿瘤免疫反应，并且这些细胞是癌症传播和转移的最重要参与者。因此，了解 MDSC 分化、扩增和募集到肿瘤微环境的因素和机制可以对其进行控制。然而，大多数研究仅用无进一步特征分析的粒细胞和单核细胞亚群来定义 MDSC。在这篇综述中，我们讨论了特定 MDSC 亚群促进癌症发生的机制。需要更好地了解 MDSC 亚群的发展和特定的分子机制，以确定治疗靶点。了解导致 MDSC 聚集的特定分子机制将能够更精确地针对这些细胞进行治疗。
