局部短程放疗在 IORT 治疗后的应用：急性毒性和美容效果评价。
Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis.
机构信息
Breast Cancer Unit, Centro Oncológico Integral Canario (COIC), Hospital Universitario San Roque, Dolores de la Rocha 5, 35001, Las Palmas, GC, Spain.
Universidad Fernando Pessoa Canarias. Dolores de La Rocha 14, 35001, Las Palmas, GC, Spain.
出版信息
Clin Transl Oncol. 2021 Jan;23(1):179-182. doi: 10.1007/s12094-020-02400-z. Epub 2020 May 22.
INTRODUCTION
Hypofractionated whole breast irradiation (HWBI) is the current standard of treatment after breast conservative surgery (BCS). Intraoperative radiotherapy (IORT) must be associated to WBI in patients showing high-risk factors of local recurrence in the definitive pathology report. The aim of this trial was to evaluate, for the first time, the acute toxicity and cosmesis of HWBI after photon-IORT.
MATERIALS AND METHODS
Twenty-six luminal breast cancer patients treated by BCS and IORT(20 Gy) were included between February and December 2019, in this prospective trial, of adjuvant HWBI (40.5 Gy/2.67 Gy/15 fractions). Acute toxicity (CTCAEv5.0) and cosmesis (Harvard scale), were assessed 3 months after treatment.
RESULTS
All patients completed their treatment without interruptions. All cases were evaluable 3 months after treatment showing no toxicity ≥ G3 and excellent/good cosmesis assessment in 88% of the patients.
CONCLUSION
HWBI seems to have similar acute toxicity and cosmesis results than conventionally fractionated WBI in combination to photon-IORT after BCS.
简介
在接受保乳手术后（BCS），部分分割全乳照射（HWBI）是目前的治疗标准。对于在明确病理学报告中显示局部复发高风险因素的患者，必须将术中放疗（IORT）与 WBI 联合应用。本试验旨在首次评估光子-IORT 后 HWBI 的急性毒性和美容效果。
材料和方法
2019 年 2 月至 12 月，我们在一项前瞻性试验中纳入了 26 例 luminal 乳腺癌患者，这些患者接受了 BCS 和 IORT（20 Gy）治疗，随后接受辅助 HWBI（40.5 Gy/2.67 Gy/15 次）。在治疗后 3 个月评估急性毒性（CTCAEv5.0）和美容效果（哈佛量表）。
结果
所有患者均未中断治疗完成了全部疗程。所有病例在治疗后 3 个月均进行了评估，无一例出现毒性≥G3，88%的患者美容效果评估为优秀/良好。
结论
HWBI 似乎与光子-IORT 联合 BCS 后常规分割 WBI 具有相似的急性毒性和美容效果。
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