出生后48小时内早产儿前降钙素参考范围：一项多中心观察性研究。

Reference ranges of Presepsin in preterm infants in the first 48 h of life: A multicenter observational study.

作者信息

Poggi Chiara, Vasarri Maria Viola, Boni Luca, Pugni Lorenza, Mosca Fabio, Dani Carlo

机构信息

Division of Neonatology and Neonatal Intensive Care, Department of Mother and Child Care, Careggi University Hospital, 3 Largo Brambilla, Florence 50141, Italy.

出版信息

Clin Chim Acta. 2020 Sep;508:191-196. doi: 10.1016/j.cca.2020.05.040. Epub 2020 May 22.

DOI:10.1016/j.cca.2020.05.040

PMID:32450079

Abstract

BACKGROUND AND OBJECTIVES

Despite low incidence of early-onset sepsis, the majority of preterm newborns receive early antibiotic prophylaxis. Our aim was to assess reference ranges of Presepsin during the first 48 h of life in preterm infants and to evaluate the possible influence of neonatal and maternal factors on its values.

METHODS

This observational study consecutively enrolled newborns ≤ 32 weeks of GA at 0-6 h of life. Enrolled infants were sampled for blood culture, complete white blood cell (WBC) count, and P-SEP at 0-6 (T) h of life and for P-SEP at 12 ± 3 (T), 24 ± 3 (T), and 48 ± 6 (T) h of life. Cases of EOS were not considered for the statistical analysis.

RESULTS

Data analysis was performed for 183 patients. P-SEP median values were 583 ng/L at T (IQR 405-800 ng/L, 5th and 95th percentiles 204 and 1200 ng/L), 614 ng/L at T (IQR 450-812 ng/L, 5th and 95th percentiles 262 and 1171 ng/L), 604 ng/L at T (IQR 445-825 ng/L, 5th and 95th percentiles 292 and 1302 ng/L) and 513 ng/L at T (IQR 371-734 ng/L, 5th and 95th percentiles 249 and 1278 ng/L). P-SEP values are negatively associated to gestational age (GA) at T, T, and T.

CONCLUSIONS

We determined for the first time the reference ranges of P-SEP during the first 48 h of life in very preterm infants and provided its percentile distribution at T, T, T and T. P-SEP measurement was affected by GA at T, T, T.

摘要

背景与目的

尽管早发型败血症发病率较低，但大多数早产新生儿仍接受早期抗生素预防治疗。我们的目的是评估早产儿出生后48小时内前降钙素原（Presepsin）的参考范围，并评估新生儿和母亲因素对其值的可能影响。

方法

这项观察性研究连续纳入出生体重≤32周、出生0至6小时的新生儿。入选婴儿在出生0至6小时（T）时进行血培养、全血细胞计数和前降钙素原（P-SEP）检测，在出生12±3小时（T）、24±3小时（T）和48±6小时（T）时进行P-SEP检测。早发型败血症（EOS）病例不纳入统计分析。

结果

对183例患者进行了数据分析。P-SEP中位数在T时为583 ng/L（四分位间距405 - 800 ng/L，第5和第95百分位数204和1200 ng/L），在T时为614 ng/L（四分位间距450 - 812 ng/L，第5和第95百分位数262和1171 ng/L），在T时为604 ng/L（四分位间距445 - 825 ng/L，第5和第95百分位数292和1302 ng/L），在T时为513 ng/L（四分位间距371 - 734 ng/L，第5和第95百分位数249和1278 ng/L）。P-SEP值在T、T和T时与胎龄（GA）呈负相关。