从山竹子中分离得到的新倍半萜和 C-甲基化黄酮。
New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens.
机构信息
State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Chin J Nat Med. 2020 May;18(5):379-384. doi: 10.1016/S1875-5364(20)30044-3.
Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S-U (1-3), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC value being 0.81 μmol·L.
植物化学研究表明，山芝麻的地上部分含有三种新的单萜或倍半萜基混合萜类化合物，分别为 frutescones S-U（1-3），以及一对新的（±）-5,7-二羟基-8-异丁酰基-6-甲基二氢黄酮醇（4）。它们的结构和绝对构型通过高分辨电喷雾质谱（HR-ESI-MS）、一维和二维核磁共振（1D 和 2D NMR）以及量子化学ECD 计算确定。化合物 1 对 LPS 激活的 RAW 264.7 巨噬细胞中 NO 生成有抑制作用，IC 值为 0.81 μmol·L。
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