Are concentrations of clusterin and beta-2-glycoprotein I dysregulated in HIV associated preeclampsia?

OBJECTIVE

To evaluate the levels of serum beta-2-glycoprotein I (βGP1) and clusterin in the duality of Pre-eclampsia and HIV.

METHOD

Stored serum samples collected from 72 pregnant women were stratified according to the pregnancy type (pre-eclamptic and healthy normotensive groups) and HIV status (positive or negative). A Bio-Plex multiplex immunoassay was used to determine the concentrations of clusterin and βGP1.

RESULTS

Clusterin concentrations differed significantly (p = 0.01) between the HIV positive (+) (mean = 123 800 ng/ml; 95 % CI: 105 400-142 200) vs. HIV negative (-) (mean = 92 190 ng /ml; 95 %CI: 75 840-108 500) groups and across all groups (p = 0.0006). Beta-2-glycoprotein I concentration differed significantly based on HIV status (p < 0.0001); HIV+ (mean = 393 649 ng/ml; 95 %CI: 30 300-467 000) vs HIV- (mean = 224 309 ng/ml; 95 %CI: 154 000-294 700) and across all groups (p < 0.0001). No significant difference was observed between normotensive and Pre-eclamptic groups for both clusterin and βGPI.

CONCLUSION

Serum concentrations of clusterin and βGPI were significantly increased in HIV positive pregnancies. It is postulated that both clusterin and βGPI may have a role in HIV disease progression. These findings need to be confirmed in studies having larger sample sizes and detailed information on anti-retroviral therapy.