Synthesis and Antioxidant Properties of New Oxazole-5(4)-one Derivatives.

OBJECTIVES

To synthesize and characterize 4-(substituted benzylidene)-2-(substituted phenyl)oxazol-5(4H)-one derivatives , and evaluate them for antioxidant activity.

MATERIALS AND METHODS

Required oxazole-5(4)-one derivatives were synthesized in two steps to obtain novel hippuric acid derivatives ; glycine and acylated appropriate benzoic acid derivatives were used and then, final compounds were obtained with condensation of with appropriate benzaldehydes . These products were purified by column chromatography using ethyl acetate/n-hexane as eluent. All the compounds were unequivocally characterized using the combination of H and C-nuclear magnetic resonance, mass spectrometry (ESI-MS), and elemental analysis. The inhibition of lipid peroxidation and its effects on hepatic cytochrome P450-dependent ethoxyresorufin-O-deethylase (EROD) enzyme were determined in rats .

RESULTS

The most active analogue on the microsomal EROD activity was which inhibited the microsomal EROD activity (89%) and was similarly better than that of the specific inhibitor caffeine (85%) at concentration.

CONCLUSION

The findings of this study indicate that the synthesized compounds, such as , display significant antioxidant activity.