药物剂型中抗炎药替诺昔康的电分析测定
Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms.
作者信息
Ağin Fatma, Atal Sena
机构信息
Karadeniz Technical University, Faculty of Pharmacy, Department of Analytical Chemistry, Trabzon, Turkey.
出版信息
Turk J Pharm Sci. 2019 Jun;16(2):184-190. doi: 10.4274/tjps.galenos.2018.60783. Epub 2019 Mar 27.
OBJECTIVES
The electro-oxidation behavior of the non-steroidal anti-inflammatory drug tenoxicam (TX) was studied on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) by cyclic voltammetry, differential pulse voltammetry (DPV), and square wave voltammetry (SWV).
MATERIALS AND METHODS
The GCE was modified with MWCNT for sensitive determination of TX by voltammetric methods.
RESULTS
The current peaks for TX occurred at around 0.520 V for DPV and 0.570 V for SWV when the potential was scanned in the positive direction. The oxidation process of TX showed irreversible and diffusion-controlled behavior. The linear responses were obtained in the range from 2×10 to 1×10 M with the limit of detection (LOD) 1.43×10 for DPV and from 8×10 to 8×10 with the LOD 9.97×10 for SWV in 1 M acetate buffer solution at pH 5.5.
CONCLUSION
Fully validated DPV and SWV were successfully applied for the determination of TX from pharmaceutical dosage form and yielded satisfying results.
目的
采用循环伏安法、差分脉冲伏安法（DPV）和方波伏安法（SWV），研究了非甾体抗炎药替诺昔康（TX）在多壁碳纳米管（MWCNT）修饰玻碳电极（GCE）上的电氧化行为。
材料与方法
用MWCNT修饰GCE，以伏安法灵敏测定TX。
结果
在正向扫描电位时，DPV法测定TX的电流峰出现在约0.520 V处，SWV法测定TX的电流峰出现在约0.570 V处。TX的氧化过程表现为不可逆的扩散控制行为。在pH 5.5的1 M醋酸盐缓冲溶液中，DPV法的线性响应范围为2×10至1×10 M，检测限（LOD）为1.43×10；SWV法的线性响应范围为8×10至8×10，检测限为9.97×10。
结论
经过充分验证的DPV和SWV成功应用于药物剂型中TX的测定，并取得了满意的结果。
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