Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9030 Old Georgetown Road, #107, Bethesda, MD, 20892, USA.
Leidos Biomedical Research, Inc, Frederick, MD, USA.
Ann Hematol. 2020 Sep;99(9):2057-2064. doi: 10.1007/s00277-020-04058-7. Epub 2020 May 27.
Sleep disturbance is common among children with sickle cell disease (SCD) and is related to neurocognitive difficulties. However, research on sleep disturbances and related variables among adults with SCD is extremely limited. The present study examined the relationship between sleep, executive functioning, and emotional functioning among 62 adults (29 females; M age = 32 years, SD = 7.79) with SCD preparing to undergo a stem cell transplant. Participants were administered a neurocognitive evaluation that included objective and subjective measures of executive functioning, and they completed PROMIS self-report measures of anxiety, depression, and pain intensity. Results showed that about 17% of participants endorsed clinically significant sleep disruptions, while 16.1% and 8% endorsed clinically significant symptoms of anxiety and depression, respectively. Sleep disturbance in these adults was not significantly correlated with objective or subjective measures of executive functioning. Moreover, anxiety, but not depression, was a significant mediator between self-reported sleep difficulties and both objective and subjective measures of executive functioning while controlling for pain intensity. Future research on sleep interventions will be essential for ameliorating the effects of sleep disturbance on executive functioning and anxiety among adults with SCD.
睡眠障碍在镰状细胞病（SCD）患儿中很常见，并且与神经认知困难有关。然而，针对 SCD 成年患者睡眠障碍及相关变量的研究极为有限。本研究调查了 62 名准备进行干细胞移植的 SCD 成年患者的睡眠、执行功能和情绪功能之间的关系。参与者接受了神经认知评估，包括执行功能的客观和主观测量，并且完成了 PROMIS 自评焦虑、抑郁和疼痛强度。结果表明，约 17%的参与者报告存在临床显著的睡眠障碍，而 16.1%和 8%的参与者分别报告存在临床显著的焦虑和抑郁症状。这些成年人的睡眠障碍与执行功能的客观或主观测量均无显著相关性。此外，在控制疼痛强度的情况下，焦虑而非抑郁是报告的睡眠困难与执行功能的客观和主观测量之间的重要中介因素。未来的睡眠干预研究对于减轻 SCD 成年患者睡眠障碍对执行功能和焦虑的影响至关重要。
