劳拉西泮与地西泮治疗癫痫持续状态的比较。
Lorazepam versus diazepam for the treatment of status epilepticus.
作者信息
Giang D W, McBride M C
机构信息
Department of Neurology, University of Rochester Medical Center, New York.
出版信息
Pediatr Neurol. 1988 Nov-Dec;4(6):358-61. doi: 10.1016/0887-8994(88)90083-5.
A retrospective study was performed to compare intravenous lorazepam and intravenous diazepam in the treatment of status epilepticus. Forty-five episodes of status epilepticus in children between the ages of 2 weeks and 18 years were reviewed. Lorazepam and diazepam proved similar in efficacy of seizure control and incidence of adverse effects. The dose of lorazepam required to control status epilepticus ranged from 0.03 to 0.22 mg/kg with a mean of 0.11 mg/kg (S.D. = 0.05 mg/kg). Among children treated with lorazepam, only children younger than 2 years of age had respiratory depression which required intubation.
进行了一项回顾性研究，以比较静脉注射劳拉西泮和静脉注射地西泮治疗癫痫持续状态的效果。回顾了2周龄至18岁儿童的45例癫痫持续状态发作。劳拉西泮和地西泮在控制癫痫发作的疗效和不良反应发生率方面相似。控制癫痫持续状态所需的劳拉西泮剂量为0.03至0.22mg/kg，平均为0.11mg/kg（标准差=0.05mg/kg）。在接受劳拉西泮治疗的儿童中，只有2岁以下的儿童出现了需要插管的呼吸抑制。
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