玻璃体内注射贝伐单抗治疗增殖性糖尿病视网膜病变合并新生血管性青光眼后的眼减压性视网膜病变

Ocular decompression retinopathy following intracameral bevacizumab injection in a case of proliferative diabetic retinopathy with neovascular glaucoma.

作者信息

Reddy Shubakar, Doshi Shreyansh, Pathengay Avinash, Panchal Bhavik

机构信息

LV Prasad Eye Institute, Hanumanthawaka Junction, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India.

出版信息

Indian J Ophthalmol. 2020 Jun;68(6):1206-1209. doi: 10.4103/ijo.IJO_1401_19.

DOI:10.4103/ijo.IJO_1401_19

PMID:32461484

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7508140/

Abstract

A 49-year-old diabetic female was diagnosed to have both eyes proliferative diabetic retinopathy (PDR) and neovascular glaucoma (NVG [rubeosis stage in the right eye and angle-closure stage in the left eye]). The right eye anterior and posterior segment new vessels regressed 2 weeks following intravitreal bevacizumab (IVB) injection. The left eye fundus revealed fibrovascular proliferation (FVP) for which panretinal photocoagulation (PRP) was started and subsequently intracameral bevacizumab (ICB) was injected. Following this intervention, the left eye new vessels of iris regressed but fundus showed multiple peripapillary white-centered intraretinal and subhyaloid hemorrhage suggestive of decompression retinopathy. Ocular decompression retinopathy presents as retinal hemorrhages following the acute lowering of the intraocular pressure (IOP). This case describes the rare occurrence of ocular decompression retinopathy following ICB in a case of PDR with NVG.

摘要

一名49岁的糖尿病女性被诊断为双眼增殖性糖尿病视网膜病变（PDR）和新生血管性青光眼（NVG，右眼为虹膜红变期，左眼为房角关闭期）。右眼在玻璃体内注射贝伐单抗（IVB）后2周，眼前后段新生血管消退。左眼眼底显示纤维血管增殖（FVP），为此开始进行全视网膜光凝（PRP），随后进行前房内注射贝伐单抗（ICB）。经过该干预后，左眼虹膜新生血管消退，但眼底出现多个以视乳头周围为中心的视网膜内和玻璃膜下白色出血，提示减压性视网膜病变。减压性视网膜病变表现为眼压（IOP）急性降低后出现的视网膜出血。本病例描述了1例PDR合并NVG患者在ICB后罕见发生的减压性视网膜病变。