Koleczko S, Wolf J
Klinik I für Innere Medizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Internist (Berl). 2020 Jul;61(7):676-681. doi: 10.1007/s00108-020-00815-y.
Immune checkpoint inhibitors (ICI) have emerged as an important treatment strategy in lung cancer in recent years. Implementation and approval status of each approved ICI will be presented by summarizing the most important phase III studies of nivolumab, pembrolizumab, atezolizumab and durvalumab. ICI are used as mono- or combination therapy with chemotherapy according to programmed cell death 1 ligand 1 (PD-L1) status and therapy line.
近年来,免疫检查点抑制剂(ICI)已成为肺癌治疗的一项重要策略。通过总结纳武利尤单抗、帕博利珠单抗、阿替利珠单抗和度伐利尤单抗最重要的III期研究,将介绍每种获批ICI的实施情况和获批状态。ICI根据程序性细胞死亡蛋白1配体1(PD-L1)状态和治疗线数,作为单药治疗或与化疗联合使用。