白藜芦醇可保护小鼠 2 细胞胚胎的线粒体免受玻璃化损伤。
Resveratrol protects the mitochondria from vitrification injury in mouse 2-cell embryos.
机构信息
Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, China; College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, 712100, China.
Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, China; College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, 712100, China.
出版信息
Cryobiology. 2020 Aug;95:123-129. doi: 10.1016/j.cryobiol.2020.05.007. Epub 2020 May 26.
Mitochondria play a key role in embryo development by providing energy. However, vitrification often causes mitochondrion damage of embryo, which further impairs embryo development. Therefore, the efficiency of embryo development after vitrification could be improved by protecting mitochondrial function from vitrification injury. The purpose of this study was to investigate the effects of resveratrol on mitochondrial damage after vitrification. The results showed that vitrification induced the abnormal mitochondrial distribution and damage mitochondrial function of mouse 2-cell embryos. However, co-culturing with resveratrol for 2 h could repair the abnormal mitochondrial distribution and mitochondrial dysfunction of embryos after vitrification. More than anything, the subsequent development ability of vitrified-thawed 2-cell embryos was significantly higher than that with no resveratrol treatment. In conclusion, resveratrol could protect the mitochondrial from injury caused by vitrification.
线粒体通过提供能量在胚胎发育中发挥关键作用。然而，玻璃化往往会导致胚胎线粒体损伤，进一步损害胚胎发育。因此，通过保护线粒体功能免受玻璃化损伤，可以提高胚胎玻璃化后的发育效率。本研究旨在探讨白藜芦醇对玻璃化后线粒体损伤的影响。结果表明，玻璃化诱导了小鼠 2 细胞胚胎线粒体分布异常和线粒体功能损伤。然而，与白藜芦醇共培养 2 小时可以修复玻璃化后胚胎的异常线粒体分布和线粒体功能障碍。更重要的是，玻璃化冻融 2 细胞胚胎的后续发育能力明显高于没有白藜芦醇处理的胚胎。总之，白藜芦醇可以保护线粒体免受玻璃化损伤。
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