高剂量碳离子放疗治疗颅底脊索瘤的长期疗效
Long-term outcomes of skull base chordoma treated with high-dose carbon-ion radiotherapy.
作者信息
Koto Masashi, Ikawa Hiroaki, Kaneko Takashi, Hagiwara Yasuhito, Hayashi Kazuhiko, Tsuji Hiroshi
机构信息
National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
出版信息
Head Neck. 2020 Sep;42(9):2607-2613. doi: 10.1002/hed.26307. Epub 2020 May 30.
BACKGROUND
We evaluated the long-term efficacy and safety of carbon-ion radiotherapy (C-ion RT) for skull base chordoma, a rare neoplasm.
METHODS
Thirty-four patients with skull base chordoma who were treated with C-ion RT were prospectively enrolled and analyzed retrospectively. C-ion RT was delivered with 60.8 Gy (relative biological effectiveness [RBE]) in 16 fractions at four fractions per week.
RESULTS
The median follow-up period was 108 months. The 5- and 9-year local control rates were 76.9% and 69.2%, respectively. The 5- and 9-year overall survival rates were 93.5% and 77.4%, respectively. Regarding grade 3 or more severe late reactions, one patient developed a grade 3 mucosal ulcer, two developed grade 4 ipsilateral optic nerve injuries, and one developed a grade 5 mucosal ulcer at 9 years and 3 months after C-ion RT.
CONCLUSION
C-ion RT with 60.8 Gy (RBE)/16 fractions is a promising treatment option for inoperable skull base chordoma.
背景
我们评估了碳离子放疗（C离子放疗）治疗罕见肿瘤——颅底脊索瘤的长期疗效和安全性。
方法
前瞻性纳入34例接受C离子放疗的颅底脊索瘤患者，并进行回顾性分析。C离子放疗总剂量为60.8 Gy（相对生物效应[RBE]），分16次给予，每周4次。
结果
中位随访期为108个月。5年和9年局部控制率分别为76.9%和69.2%。5年和9年总生存率分别为93.5%和77.4%。关于3级或更严重的晚期反应，1例患者出现3级黏膜溃疡，2例出现4级同侧视神经损伤，1例在C离子放疗后9年3个月出现5级黏膜溃疡。
结论
60.8 Gy（RBE）/16次分割的C离子放疗是不可切除颅底脊索瘤的一种有前景的治疗选择。
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