Department of Pharmacy, Jing' an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing' An Branch), Shanghaii, 200040, China,
Department of Anesthesiology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, 201821, China.
Front Biosci (Landmark Ed). 2020 Jun 1;25(10):1913-1924. doi: 10.2741/4885.
Diabetic nephropathy (DN) is a major cause of chronic kidney disease characterized by insulin resistance and lipid deposition in tissues. To this end, we examined the effect of Resveratrol (RES) in streptozotocin (STZ) induced diabetic nephropathy. RES, in a dose dependent manner, decreased the insulin resistance, and improved kidney function and lipid metabolism in STZ treated rats. RES treatment increased p-AMPK alpha/AMPK alpha and p-ULK1 S777/ULK1 and the autophagy related proteins (Beclin1, LC3 II/I) and its effects on TC and improvement in insulin resistence were quenched by the inhibitor of autophagy, 3-MA. Together, these results suggest that the effect of RES in treatment of DN may involve AMPK alpha/mTOR-mediated autophagy.
糖尿病肾病（DN）是一种主要的慢性肾脏病，其特征是组织中存在胰岛素抵抗和脂质沉积。为此，我们研究了白藜芦醇（RES）对链脲佐菌素（STZ）诱导的糖尿病肾病的影响。RES 以剂量依赖的方式降低了胰岛素抵抗，并改善了 STZ 处理大鼠的肾功能和脂质代谢。RES 处理增加了 p-AMPK alpha/AMPK alpha 和 p-ULK1 S777/ULK1 以及自噬相关蛋白（Beclin1、LC3 II/I），其对 TC 的影响和对胰岛素抵抗的改善被自噬抑制剂 3-MA 抑制。综上所述，这些结果表明，RES 在治疗 DN 中的作用可能涉及 AMPK alpha/mTOR 介导的自噬。
