Yuan Binke, Zhang Nan, Yan Jing, Cheng Jingliang, Lu Junfeng, Wu Jinsong
Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen, China.
Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Glioma Surgery Division, Neurologic Surgery Department, Huashan Hospital, Fudan University, Shanghai, China.
Cortex. 2020 Aug;129:141-157. doi: 10.1016/j.cortex.2020.04.015. Epub 2020 May 7.
Language processing relies on both a functionally specialized language network and a domain-general cognitive control network. Yet, how the two networks reorganize after damage resulting from diffuse and progressive glioma remains largely unknown. To address this issue, 130 patients with left cerebral gliomas, including 77 patients with low-grade glioma (LGG, WHO grade Ⅰ/II), 53 patients with high-grade glioma (HGG, WHO grade III/IV) and 38 healthy controls (HC) were adopted. The changes in resting-state functional connectivity (rsFC) of the language network and the cingulo-opercular/fronto-parietal (CO-FP) network were examined using network-based statistics. We found that tumor grade negatively correlated with language scores and language network integrity. Compared with HCs, patients with LGGs exhibited slight language deficits, both decreased and increased changes in rsFC of language network, and nearly normal CO-FP network. Patients with HGGs had significantly lower language scores than those with LGG and exhibited more severe language and CO-FP network disruptions than HCs or patients with LGGs. Moreover, we found that in patients with HGGs, the decreased rsFCs of language network were positively correlated with language scores. Together, our findings suggest tumor grade-related network reorganization of both language and control networks underlie the different levels of language impairments observed in patients with gliomas.
语言处理依赖于功能专门化的语言网络和领域通用的认知控制网络。然而，弥漫性进展性胶质瘤导致损伤后这两个网络如何重新组织在很大程度上仍不清楚。为了解决这个问题，我们纳入了130例左侧脑胶质瘤患者，包括77例低级别胶质瘤（LGG，世界卫生组织Ⅰ/Ⅱ级）患者、53例高级别胶质瘤（HGG，世界卫生组织Ⅲ/Ⅳ级）患者和38名健康对照者（HC）。使用基于网络的统计方法检查语言网络和扣带回-脑岛/额顶叶（CO-FP）网络静息态功能连接（rsFC）的变化。我们发现肿瘤级别与语言评分和语言网络完整性呈负相关。与健康对照者相比，LGG患者表现出轻微的语言缺陷、语言网络rsFC的减少和增加变化，以及近乎正常的CO-FP网络。HGG患者的语言评分显著低于LGG患者，并且与健康对照者或LGG患者相比，表现出更严重的语言和CO-FP网络破坏。此外，我们发现，在HGG患者中，语言网络rsFC的降低与语言评分呈正相关。总之，我们的研究结果表明，胶质瘤患者中观察到的不同程度语言障碍的基础是肿瘤级别相关的语言和控制网络的网络重组。
