Department of Endocrinology, Huaian Hospital of Huaian District, Huaian, 223200, China.
Department of Clinical Medicine, Yangzhou University Medical College, Yangzhou, 225009, China.
J Endocrinol Invest. 2021 Feb;44(2):311-319. doi: 10.1007/s40618-020-01300-x. Epub 2020 May 30.
Gene polymorphisms of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6) may influence the risk of Graves' disease, but the results of so far published studies remain inconclusive. Therefore, the authors conducted this meta-analysis to assess relationships between TNF-α/IL-1/IL-6 polymorphisms and the risk of Graves' disease by pooling the findings of all relevant studies.
A comprehensive literature searching of Pubmed, Embase, Web of Science and CNKI was conducted by the authors, and twenty-eight studies were found to be eligible for pooled analyses.
The pooled meta-analyses results showed that genotypic frequencies of TNF-α rs1800629, IL-1A rs1800587, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms among patients with Graves' disease and control subjects differed significantly. Moreover, we found that genotypic frequencies of TNF-α rs1800629 and IL-6 rs1800795 polymorphisms among patients with Graves' disease and control subjects in Caucasians differed significantly, and genotypic frequencies of IL-1A rs1800587, IL-1B rs16944, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms among patients with Graves' disease and control subjects in Asians also differed significantly. Nevertheless, we did not detect such genotypic frequencies differences for TNF-α rs361525 and IL-1B rs1143627 polymorphisms.
This meta-analysis suggests that TNF-α rs1800629, IL-1A rs1800587, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms may influence the risk of Graves' disease in overall population. Moreover, TNF-α rs1800629 and IL-6 rs1800795 polymorphisms may influence the risk of Graves' disease in Caucasians, while IL-1A rs1800587, IL-1B rs16944, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms may influence the risk of Graves' disease in Asians.
肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）和白细胞介素-6（IL-6）等促炎细胞因子的基因多态性可能影响格雷夫斯病的发病风险，但迄今为止发表的研究结果仍存在争议。因此，作者进行了这项荟萃分析，通过合并所有相关研究的结果来评估 TNF-α/IL-1/IL-6 多态性与格雷夫斯病风险之间的关系。
作者对 Pubmed、Embase、Web of Science 和 CNKI 进行了全面的文献检索，发现 28 项研究符合荟萃分析的纳入标准。
荟萃分析结果显示，格雷夫斯病患者和对照组 TNF-α rs1800629、IL-1A rs1800587、IL-6 rs1800795 和 IL-6 rs1800796 基因型频率存在显著差异。此外，我们发现，TNF-α rs1800629 和 IL-6 rs1800795 基因型频率在高加索人群中格雷夫斯病患者和对照组之间存在显著差异，而 IL-1A rs1800587、IL-1B rs16944、IL-6 rs1800795 和 IL-6 rs1800796 基因型频率在亚洲人群中格雷夫斯病患者和对照组之间也存在显著差异。然而，我们没有检测到 TNF-α rs361525 和 IL-1B rs1143627 多态性的这种基因型频率差异。
本荟萃分析提示 TNF-α rs1800629、IL-1A rs1800587、IL-6 rs1800795 和 IL-6 rs1800796 多态性可能影响总体人群格雷夫斯病的发病风险。此外，TNF-α rs1800629 和 IL-6 rs1800795 多态性可能影响高加索人群格雷夫斯病的发病风险，而 IL-1A rs1800587、IL-1B rs16944、IL-6 rs1800795 和 IL-6 rs1800796 多态性可能影响亚洲人群格雷夫斯病的发病风险。
