Khristov V, Petkova M, Tsanev A
Vutr Boles. 1988;27(6):35-8.
30 insulin-dependent, C-peptide negative diabetic patients were examined with the help of biostator. The mean age of the patients was 29 years, the mean duration of the diabetes was 7 years and the mean index of body mas was 22. For the period from 0 to 8 o'clock in the morning the blood sugar level and the speed of the insulin infusion in order to maintain euglycemic level were examined at 1/2 hour intervals. The mean blood sugar level for the period 5-8 o'clock (5.71 +/- 0.31 mmol/l) was reliably higher (p less than 0.05) than that for the period 0-5 o'clock (5.4 +/- 0.18 mmol/l). The speed of the insulin infusion for the period 5-8 o'clock (0.52 +/- 0.09 IU/kg/min) was also reliably higher (p less than 0.02) than that for the period 0-5 o'clock (0.4 +/- 0.06 IU/kg/min). These two indices were correlated with the somatotropic hormone and hydrocortisone levels at 2 and 8 o'clock. The possible pathogenetic mechanisms of this "morning phenomenon" in diabetes is discussed.
借助生物人工肾对30例胰岛素依赖型、C肽阴性糖尿病患者进行了检查。患者的平均年龄为29岁，糖尿病平均病程为7年，平均体重指数为22。在上午0点至8点期间，每隔半小时检查一次血糖水平以及为维持血糖正常水平而进行的胰岛素输注速度。5点至8点期间的平均血糖水平（5.71±0.31毫摩尔/升）显著高于（p<0.05）0点至5点期间的平均血糖水平（5.4±0.18毫摩尔/升）。5点至8点期间的胰岛素输注速度（0.52±0.09国际单位/千克/分钟）也显著高于（p<0.02）0点至5点期间的胰岛素输注速度（0.4±0.06国际单位/千克/分钟）。这两个指标与2点和8点时的生长激素及氢化可的松水平相关。文中讨论了糖尿病中这种“黎明现象”可能的发病机制。
