CD25 FOXP3 和 CD4 CD25 细胞在重度和轻度子痫前期孕妇蜕膜组织中的分布：与健康妊娠的比较。
CD25 FOXP3 and CD4 CD25 cells distribution in decidual departments of women with severe and mild pre-eclampsia: Comparison with healthy pregnancies.
机构信息
Department of Obstetrics, Gynecology University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.
Faculty of Health Studies, University of Mostar, Mostar, Bosnia and Herzegovina.
出版信息
Am J Reprod Immunol. 2020 Sep;84(3):e13281. doi: 10.1111/aji.13281. Epub 2020 Jun 16.
PROBLEM
The aim of this study was to quantify and compare the distribution of regulatory CD25 FOXP3 and activated CD4 CD25 T cells in decidua basalis and parietalis of severe and mild pre-eclampsia (PE) to normal healthy pregnancies.
METHOD OF STUDY
Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence.
RESULTS
The total number of CD25 FOXP3 cells/mm in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4 CD25 cells/mm in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25 FOXP3 and CD4 CD25 cells in decidua parietalis was decreased in both PE groups.
CONCLUSION
Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.
问题
本研究旨在定量比较和比较严重和轻度子痫前期（PE）与正常健康妊娠的蜕膜基底和蜕膜壁中调节性 CD25 FOXP3 和激活的 CD4 CD25 T 细胞的分布。
研究方法
通过免疫组织化学和双重免疫荧光分析了 13 例轻度 PE、15 例重度 PE 和 19 例正常足月妊娠妇女的蜕膜组织（蜕膜基底和蜕膜壁）。
结果
蜕膜基底中 CD25 FOXP3 细胞/mm 的总数在严重和轻度 PE 与正常妊娠组中减少。蜕膜基底中 CD4 CD25 细胞/mm 的总数在重度 PE 与正常妊娠组中减少。在两个 PE 组中，蜕膜壁中的 CD25 FOXP3 和 CD4 CD25 细胞数量均减少。
结论
我们的数据表明，PE 的免疫变化反映在蜕膜基底和蜕膜壁上，并强调了在两个蜕膜部位对 T 细胞进行特征描述的重要性。
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