高 ERCC1 表达的胃癌特征及 ERCC1 表达的预后价值。

Characteristics of Gastric Carcinomas With High ERCC1 Expression and the Prognostic Value of ERCC1 Expression.

机构信息

Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.

出版信息

Anticancer Res. 2020 Jun;40(6):3203-3208. doi: 10.21873/anticanres.14301.

DOI:10.21873/anticanres.14301

PMID:32487614

Abstract

BACKGROUND/AIM: We aimed to evaluate the characteristics of gastric carcinoma with high excision repair cross complementing 1 (ERCC1) expression and the prognostic value of ERCC1 expression.

MATERIALS AND METHODS

ERCC1 expression was evaluated by immunohistochemistry in 309 surgically resected gastric carcinoma specimens using a tissue microarray. Cancer-related survival was analysed using competing risk analysis.

RESULTS

Compared to ERCC1-low gastric carcinomas, ERCC1-high gastric carcinomas showed less local invasion (p=0.0013), lower N stage (p=0.0302), earlier pTNM stage (p=0.0003), and less frequent recurrence (p=0002). Patients with ERCC1-high gastric carcinoma showed lower cumulative incidence function estimate of cancer-related death [3.37; 95% confidence intervaI (CI)=0.89-8.75] than did those with ERCC1-low gastric carcinoma (17.12; 95% CI=12.24-22.69; p-value by Gray's test=0.0012). Adjusted proportional sub-distribution hazard ratio for cancer-related death in the patients with ERCC1-high tumour was 0.272 (95% CI=0.084-0.878; p=0.0295).

CONCLUSION

High ERCC1 expression may be an independent positive prognostic marker for gastric carcinoma.

摘要

背景/目的：本研究旨在评估高切除修复交叉互补基因 1（ERCC1）表达的胃癌的特征及其 ERCC1 表达的预后价值。

材料与方法

采用组织微阵列免疫组化法检测 309 例手术切除的胃癌标本中 ERCC1 的表达。采用竞争风险分析评估癌症相关生存情况。

结果

与 ERCC1 低表达的胃癌相比，ERCC1 高表达的胃癌侵袭性更低（p=0.0013），N 分期更低（p=0.0302），pTNM 分期更早（p=0.0003），复发率更低（p=0.0002）。与 ERCC1 低表达的胃癌患者相比，ERCC1 高表达的胃癌患者的癌症相关死亡累积发生率估计值较低[3.37；95%置信区间（CI）=0.89-8.75]（p 值为 Gray 检验=0.0012）。校正后的癌症相关死亡比例风险亚分布比（hazard ratio，HR）在 ERCC1 高肿瘤患者中为 0.272（95% CI=0.084-0.878；p=0.0295）。