Mozayeni Farnaz, Rezaee Seyed Abdolrahim, Jabbari Azad Farahzad, Shabestari Mahmoud, Faridhosseini Reza, Rafatpanah Houshang, Yousefzadeh Hadis, Garivani Yousef Ali, Jarahi Lida, Valizadeh Narges, Sabet Faezah, Moshirahmadi Sharare, Mohammadi Fatemeh Sadat, Shabestari Mohammad
Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunology Research Center, Inflammation and Inflammatory Disease Division, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2020 Apr;23(4):500-506. doi: 10.22038/ijbms.2020.36317.8649.
Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of northeastern Iran.
Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary angiography. A real-time PCR, TaqMan method, to quantify HTLV-1 proviral load (PVL), and routine hematological and biochemical tests were performed for study subjects.
Twenty nine patients were HTLV-1+CAD+ and 13 cases were HTLV-1+CAD-. Although, there were no significant differences for risk factors like FBS, HDL, triglyceride, systolic and diastolic blood pressure (Cbp, Dbp), waist circumference (WC), hip circumference (WL), cholesterol (=0.003), and LDL (=0.007) levels, and monocyte count (=0.05) had meaningful differences. The mean HTLV-1 PVL in HTLV-1+CAD+ subjects was 992.62±120 which was higher compared with HTLV-1+CAD- group (406.54±302 copies/104 PBMCs). Moreover, HTLV-1 PVL in males (833±108) was lower compared with females (1218±141 copies/104 PBMCs) (=0.05). Patients with HTLV-1-PVL of more than 500 copies/104 had more diffused atherosclerosis plaque than patients with less than 500 (OR=6.87, 95% CI=1.34-35.05; =0.016). Furthermore, patients with diffused coronary atherosclerosis had significantly higher levels of HTLV-1 PVL than patients with middle, proximal, and normal location of coronary sclerotic lesions (<0.05).
Taken together, in endemic area, HTLV-1 infection, more likely is a facilitating factor for heart complications and the high HTLV-1 PVL might affect CAD manifestations.
冠状动脉疾病（CAD）在全球范围内是一种危及生命的疾病。在本研究中，评估了伊朗东北部一个流行地区HTLV - 1感染在心脏受累方面的作用。
对接受冠状动脉造影的受试者进行HTLV - 1感染的血清学和分子检测。采用实时PCR（TaqMan法）定量HTLV - 1前病毒载量（PVL），并对研究对象进行常规血液学和生化检测。
29例患者为HTLV - 1+CAD+，13例为HTLV - 1+CAD-。虽然空腹血糖（FBS）、高密度脂蛋白（HDL）、甘油三酯、收缩压和舒张压（收缩压Cbp、舒张压Dbp）、腰围（WC）、臀围（WL）、胆固醇（P = 0.003）、低密度脂蛋白（P = 0.007）水平等危险因素无显著差异，但单核细胞计数（P = 0.05）有显著差异。HTLV - 1+CAD+受试者的平均HTLV - 1 PVL为992.62±120，高于HTLV - 1+CAD-组（406.54±302拷贝/104个外周血单个核细胞）。此外，男性的HTLV - 1 PVL（833±108）低于女性（1218±141拷贝/104个外周血单个核细胞）（P = 0.05）。HTLV - 1 - PVL超过500拷贝/104的患者比低于500拷贝/104的患者有更多弥漫性动脉粥样硬化斑块（比值比OR = 6.87，95%可信区间CI = 1.34 - 35.05；P = 0.016）。此外，弥漫性冠状动脉粥样硬化患者的HTLV - 1 PVL水平显著高于冠状动脉硬化病变位于中段、近端和正常位置的患者（P<0.05）。
综上所述，在流行地区，HTLV - 1感染更有可能是心脏并发症的促进因素，高HTLV - 1 PVL可能影响CAD的表现。
