大剂量静脉注射地西泮后出现构音障碍。

Dysarthria after large doses of intravenous diazepam.

作者信息

Ishikawa T, Hato M, Tauchi A, Wada Y

机构信息

Department of Pediatrics, Nagoya City University Medical School, Japan.

出版信息

Jpn J Psychiatry Neurol. 1988 Dec;42(4):759-61. doi: 10.1111/j.1440-1819.1988.tb01163.x.

DOI:10.1111/j.1440-1819.1988.tb01163.x

PMID:3249473

Abstract

This is a description of a 34-month-old girl with dysarthria after a dosage of 37.5 mg/15 hours of intravenous diazepam (DZP). Dysarthria lasted 180 hours after the final dose. However, her respiration and blood pressure were normal, and disturbance of consciousness was mild and normalized at 77 hours. The clinical correlations of the concentrations of DZP and its active metabolite are discussed.

摘要

这是一名34个月大女童的病例描述，其在静脉注射了37.5毫克/15小时的地西泮（DZP）后出现构音障碍。构音障碍在最后一剂后持续了180小时。然而，她的呼吸和血压正常，意识障碍较轻，并在77小时后恢复正常。文中讨论了地西泮及其活性代谢物浓度的临床相关性。