Department of Integrative Anatomy, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Department of Neurobiology, Morehouse School of Medicine, Atlanta GA 30310, United States.
Curr Protein Pept Sci. 2020;21(10):985-992. doi: 10.2174/1389203721666200605170938.
Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcriptional regulation by a cleaved kinase domain translocated to nuclei. Interestingly, at a higher level, TRPM7 participates in several biological processes in the nervous and cardiovascular systems, in which excitatory responses in neurons and cardiomyocytes are critical for their function. Here, we review the roles of TRPM7 in cells involved in the nervous and cardiovascular systems and discuss its potential as a future therapeutic target.
瞬时受体电位 melastatin 7（TRPM7）与密切相关的 TRPM6 一起，是具有双重功能的独特通道：阳离子通透性和激酶活性。与 TRPM6 的有限组织分布相比，TRPM7 在组织中广泛表达，因此在生理和病理生理上与多种细胞功能有关。TRPM7 独特结构赋予双重离子通道和激酶活性的发现揭示了新的奇特的生物学功能，如 Mg2+稳态、细胞内 Ca2+闪烁，甚至通过切割激酶结构域转移到细胞核内的核转录调控。有趣的是，在更高的水平上，TRPM7 参与神经系统和心血管系统中的几个生物学过程，其中神经元和心肌细胞的兴奋反应对其功能至关重要。在这里，我们综述了 TRPM7 在涉及神经系统和心血管系统的细胞中的作用，并讨论了它作为未来治疗靶点的潜力。
