State Key laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of orthodontics, West China School of Stomatology Sichuan University, Chengdu 610041, China.
West China Hospital of Clinical Medicine, Sichuan University, Chengdu 610041, China.
Chin J Nat Med. 2020 Jun;18(6):425-435. doi: 10.1016/S1875-5364(20)30050-9.
Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. This article intends to provide a novel insight for further development of emodin, hoping to reveal the potential of emodin and necessity of further studies in this field.
大黄素（1,3,8-三羟基-6-甲基蒽醌）是一种从药用植物的根和树皮中提取的蒽醌类化合物，包括大黄、芦荟、虎杖、何首乌和虎杖。本综述旨在为大黄素在药理学活性和毒性方面提供科学总结，以确定其在人类特定器官中作为新药的治疗潜力。基于抗癌、抗炎、抗氧化、抗菌、抗病毒、抗糖尿病、免疫抑制和促进成骨等基本特性，大黄素有望成为癌症、心肌梗死、动脉粥样硬化、糖尿病、急性胰腺炎、哮喘、牙周炎、脂肪肝和神经退行性疾病的有效预防和治疗药物。本文旨在为大黄素的进一步发展提供新的见解，希望揭示大黄素的潜力和该领域进一步研究的必要性。
