运动神经元病中的手部分离现象：肌肉厚度的超声评估。
Split-hand phenomenon in motor neuron diseases: Sonographic assesment of muscle thickness.
机构信息
Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
出版信息
Clin Neurophysiol. 2020 Aug;131(8):1721-1725. doi: 10.1016/j.clinph.2020.04.163. Epub 2020 May 22.
OBJECTIVE
To explore the diagnostic accuracy of the split-hand index (SHI) for amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) using sonographic assessment of muscle thickness.
METHODS
We performed a prospective sonographic assessment of hand muscle thickness in 59 controls, 87 patients with ALS, and 33 patients with SMA. We determined the diagnostic accuracy of SHI for differentiating patients with ALS and SMA from controls.
RESULTS
Patients with ALS and SMA had significantly lower muscle thickness and SHI values compared with controls. SHI showed excellent diagnostic accuracy for differentiating ALS from controls, and good diagnostic accuracy for differentiating SMA from controls.
CONCLUSIONS
SHI determined by sonographic measurement of hand muscle thickness seems to be a promising tool for the diagnosis of ALS and may be added easily when performing neuromuscular ultrasound.
SIGNIFICANCE
SHI determined by sonographic measurement of hand muscle thickness can differentiate between healthy subjects and patients with ALS and SMA.
目的
利用肌肉厚度超声评估，探讨分指指数（SHI）对肌萎缩侧索硬化症（ALS）和脊髓性肌萎缩症（SMA）的诊断准确性。
方法
我们对 59 名健康对照者、87 名 ALS 患者和 33 名 SMA 患者进行了前瞻性手部肌肉厚度超声评估。我们确定了 SHI 区分 ALS 和 SMA 患者与对照组的诊断准确性。
结果
与对照组相比，ALS 和 SMA 患者的肌肉厚度和 SHI 值明显更低。SHI 对区分 ALS 患者与对照组具有优异的诊断准确性，对区分 SMA 患者与对照组具有良好的诊断准确性。
结论
通过手部肌肉厚度超声测量确定的 SHI 似乎是一种有前途的 ALS 诊断工具，在进行神经肌肉超声检查时很容易添加。
意义
通过手部肌肉厚度超声测量确定的 SHI 可区分健康受试者与 ALS 和 SMA 患者。
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