前瞻性观察数据有助于了解和未来管理林奇综合征：来自前瞻性林奇综合征数据库（PLSD）的见解。
Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD).
机构信息
Department of Surgery, Helsinki University Hospital, Helsinki, Finland.
Department of Surgical Oncology, Johns Hopkins University, Baltimore, USA.
出版信息
Fam Cancer. 2021 Jan;20(1):35-39. doi: 10.1007/s10689-020-00193-2. Epub 2020 Jun 8.
Abstract
The Prospective Lynch Syndrome Database (PLSD) has been developed as an international, multicentre, prospective, observational study that aims to provide age and organ-specific cancer risks according to gene and gender, estimates of survival after cancer and information on the effects of interventions. Recent reports from PLSD provided improved estimates of cancer risks and survival and showed that different time intervals between surveillance colonoscopies did not affect the incidence, stage or prognosis of colorectal cancer. The PLSD reports suggest that current management guidelines for Lynch syndrome should be revised in light of the different gene and gender-specific cancer risks and the good prognosis for the most commonly associated cancers.In this review, we describe the discrepancies between the current management guidelines for Lynch Syndrome and the most recent prospective observational studies, indicating the areas of further research.
摘要
前瞻性林奇综合征数据库（PLSD）是一项国际性的、多中心的、前瞻性的观察性研究，旨在根据基因和性别提供特定年龄和器官的癌症风险、癌症后的生存估计以及干预措施效果的信息。PLSD 的最新报告提供了改进的癌症风险和生存估计，并表明不同的结直肠癌监测结肠镜检查时间间隔不会影响结直肠癌的发病率、分期或预后。PLSD 的报告表明，应根据不同的基因和性别特异性癌症风险以及最常见相关癌症的良好预后，对林奇综合征的现行管理指南进行修订。在这篇综述中，我们描述了当前林奇综合征管理指南与最新前瞻性观察性研究之间的差异，并指出了进一步研究的领域。
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