Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA, United States.
Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, United States.
Front Immunol. 2020 May 19;11:769. doi: 10.3389/fimmu.2020.00769. eCollection 2020.
Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in metabolic homeostasis and meta-inflammation. Over the last decade, new insights have emerged on the mechanism and biological significance of these interactions in the context of diet-induced disorders such as obesity and type-2 diabetes. Complications of energy metabolism drive most diet-induced metabolic disorders, which results in low-grade chronic inflammation, thereby affecting proper function of many vital organs involved in energy homeostasis, such as the brain, liver, kidney, heart and adipose tissue. Here, we discuss how heparan, chondroitin and keratan sulfate proteoglycans modulate obesity-induced metabolic dysfunction and low-grade inflammation that impact the initiation and progression of obesity-associated morbidities.
蛋白聚糖是细胞表面和细胞外基质中存在的糖蛋白的特定亚类，它们与参与代谢稳态和代谢炎症的大量蛋白质相互作用。在过去的十年中，人们对这些相互作用在饮食引起的肥胖和 2 型糖尿病等疾病中的机制和生物学意义有了新的认识。能量代谢的并发症驱动着大多数饮食引起的代谢紊乱，导致低度慢性炎症，从而影响参与能量稳态的许多重要器官的正常功能，如大脑、肝脏、肾脏、心脏和脂肪组织。在这里，我们讨论了肝素、软骨素和角质素硫酸蛋白聚糖如何调节肥胖引起的代谢功能障碍和低度炎症，从而影响肥胖相关疾病的发生和发展。
