Guo Yafei, Harutyunyan Syuzanna R
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Beilstein J Org Chem. 2020 May 14;16:1006-1021. doi: 10.3762/bjoc.16.90. eCollection 2020.
Copper-catalysed asymmetric C-C bond-forming reactions using organometallic reagents have developed into a powerful tool for the synthesis of complex molecules with single or multiple stereogenic centres over the past decades. Among the various acceptors employed in such reactions, those with a heterocyclic core are of particular importance because of the frequent occurrence of heterocyclic scaffolds in the structures of chiral natural products and bioactive molecules. Hence, this review focuses on the progress made over the past 20 years for heterocyclic acceptors.
在过去几十年里，使用有机金属试剂的铜催化不对称碳-碳键形成反应已发展成为合成具有单个或多个立体中心的复杂分子的有力工具。在这类反应中使用的各种受体中，具有杂环核心的受体尤为重要，因为在手性天然产物和生物活性分子的结构中经常出现杂环骨架。因此，本综述重点关注过去20年中杂环受体方面取得的进展。
