B细胞耗竭对与免疫检查点抑制相关的免疫相关不良事件的影响。
The effects of B cell depletion on immune related adverse events associated with immune checkpoint inhibition.
作者信息
Risbjerg Rasmus Strøm, Hansen Mie Vennize, Sørensen Anne Sofie, Kragstrup Tue Wenzel
机构信息
Department of Biomedicine, Aarhus University, Skou Building, 8000 Aarhus C, Denmark.
Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Exp Hematol Oncol. 2020 May 25;9:9. doi: 10.1186/s40164-020-00167-1. eCollection 2020.
This letter describes the potential effect of B cell depletion on immune related adverse events associated with immune checkpoint inhibition. B cell depleting agents such as rituximab reduce B cell to plasma cell differentiation and antibody production. This treatment strategy is used in several immune mediated inflammatory diseases such as rheumatoid arthritis and small vessel vasculitis. The immune related adverse events associated with immune checkpoint inhibition resemble immune mediated inflammatory diseases. Here, we report a lower incidence of hypothyroidism in a trial of combined B cell depletion and immune checkpoint inhibitor treatment compared with studies of immune checkpoint inhibitor monotherapy. This letter aims to increase awareness of the immune related adverse events associated with immune checkpoint inhibition in future clinical trials of immune checkpoint inhibition together with B cell depletion (primarily trials of B cell lymphomas). Hopefully, observations from these clinical trials can guide future treatment strategies to treat or prevent immune related adverse events associated with immune checkpoint inhibition.
这封信描述了B细胞耗竭对与免疫检查点抑制相关的免疫相关不良事件的潜在影响。诸如利妥昔单抗等B细胞耗竭剂可减少B细胞向浆细胞的分化及抗体产生。这种治疗策略用于多种免疫介导的炎症性疾病，如类风湿性关节炎和小血管血管炎。与免疫检查点抑制相关的免疫相关不良事件类似于免疫介导的炎症性疾病。在此，我们报告，与免疫检查点抑制剂单药治疗的研究相比，在一项B细胞耗竭与免疫检查点抑制剂联合治疗的试验中，甲状腺功能减退的发生率较低。这封信旨在提高人们对在未来免疫检查点抑制联合B细胞耗竭（主要是B细胞淋巴瘤试验）的临床试验中与免疫检查点抑制相关的免疫相关不良事件的认识。希望这些临床试验的观察结果能够指导未来治疗或预防与免疫检查点抑制相关的免疫相关不良事件的治疗策略。
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