Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
Department of Sport and Health Sciences, Technische Universität München, Georg-Brauchle-Ring 60/62, 80992 Munich, Germany.
Eur Radiol Exp. 2020 Jun 10;4(1):35. doi: 10.1186/s41747-020-00162-5.
We investigated the composition of the gluteal (gluteus maximus, medius, and minimus) and quadriceps (rectus femoris, vastus lateralis, medialis, and intermedius) muscle groups and its associations with femoral bone marrow using chemical shift encoding-based water-fat magnetic resonance imaging (CSE-MRI) to improve our understanding of muscle-bone interaction.
Thirty healthy volunteers (15 males, aged 30.5 ± 4.9 years [mean ± standard deviation]; 15 females, aged 29.9 ± 7.1 years) were recruited. A six-echo three-dimensional spoiled gradient-echo sequence was used for 3-T CSE-MRI at the thigh and hip region. The proton density fat fraction (PDFF) of the gluteal and quadriceps muscle groups as well as of the femoral head, neck, and greater trochanter bone marrow were extracted and averaged over both sides.
PDFF values of all analysed bone marrow compartments were significantly higher in men than in women (p ≤ 0.047). PDFF values of the analysed muscles showed no significant difference between men and women (p ≥ 0.707). After adjusting for age and body mass index, moderate significant correlations of PDFF values were observed between the gluteal and quadriceps muscle groups (r = 0.670) and between femoral subregions (from r = 0.613 to r = 0.655). Regarding muscle-bone interactions, only the PDFF of the quadriceps muscle and greater trochanter bone marrow showed a significant correlation (r = 0.375).
The composition of the muscle and bone marrow compartments at the thigh and hip region in young, healthy subjects seems to be quite distinct, without evidence for a strong muscle-bone interaction.
我们使用基于化学位移编码的水脂磁共振成像（CSE-MRI）来研究臀肌（臀大肌、臀中肌和臀小肌）和股四头肌（股直肌、股外侧肌、股内侧肌和股中间肌）的组成及其与股骨骨髓之间的关系，以增进对肌肉-骨骼相互作用的理解。
招募了 30 名健康志愿者（15 名男性，年龄 30.5±4.9 岁[均值±标准差]；15 名女性，年龄 29.9±7.1 岁）。使用六回波三维扰相梯度回波序列在大腿和臀部进行 3-T CSE-MRI。提取并平均双侧臀肌和股四头肌以及股骨头、颈和大转子骨髓的质子密度脂肪分数（PDFF）。
所有分析的骨髓腔 PDFF 值在男性中均显著高于女性（p≤0.047）。男性和女性之间肌肉的 PDFF 值无显著差异（p≥0.707）。在校正年龄和体重指数后，臀肌和股四头肌之间（r=0.670）以及股骨各亚区之间（r=0.613 至 r=0.655）的 PDFF 值存在中度显著相关性。关于肌肉-骨骼相互作用，仅股四头肌和大转子骨髓的 PDFF 值存在显著相关性（r=0.375）。
在年轻健康的受试者中，大腿和臀部的肌肉和骨髓腔组成似乎相当不同，没有强有力的肌肉-骨骼相互作用的证据。
