美芬妥英对鸽子按程序控制反应的影响。

Effects of mephenytoin on schedule-controlled responding in the pigeon.

作者信息

Pellettiere V, Delaney D, Schlinger H, Poling A

机构信息

Department of Psychology, Western Michigan University, Kalamazoo 49008.

出版信息

Pharmacol Biochem Behav. 1988 Sep;31(1):233-7. doi: 10.1016/0091-3057(88)90339-5.

DOI:10.1016/0091-3057(88)90339-5

PMID:3252256

Abstract

Acute and chronic effects of mephenytoin (30-360 mg/kg) were examined in pigeons responding under a multiple fixed-ratio 50 fixed-interval 90-sec schedule of food delivery. The highest dose administered acutely (240 mg/kg) produced substantial reductions in rate of responding under both components of the multiple schedule; the effects of other doses were small and inconsistent. With chronic exposure tolerance appeared to develop to the rate-decreasing effects of the drug.

摘要

在鸽子按照固定比率50、固定间隔90秒的多次食物递送时间表做出反应的情况下，研究了美芬妥英（30 - 360毫克/千克）的急性和慢性效应。急性给予的最高剂量（240毫克/千克）使多次时间表两个部分下的反应率大幅降低；其他剂量的影响较小且不一致。长期接触后，似乎对该药物的反应率降低效应产生了耐受性。