Elston J S, Marsden C D, Grandas F, Quinn N P
Department of Clinical Ophthalmology, Moorfields Eye Hospital, London, UK.
Eye (Lond). 1988;2 ( Pt 4):435-9. doi: 10.1038/eye.1988.79.
Two hundred and seventy-two patients with idiopathic blepharospasm were reviewed to establish the role of local eye disease in their illness. The majority of patients (57%) had symptoms at the onset of their illness such as dryness of the eyes, grittiness, irritation or photophobia suggesting eye lid or ocular surface disease. Detailed ophthalmological examination at the time of presentation had been carried out in 170 of the 272 cases; 64% of these patients had ocular symptoms, and 40% had demonstrable ocular surface or eye lid pathology. Such pathology was usually bilateral, chronic and resistant to local treatment. Blepharospasm developed in these patients after a long latent period, often of many years. Unilateral pathology was acute, normally responded well to local treatment, but was followed by the development of bilateral blepharospasm usually within six months. Amongst all 272 patients, those without ocular symptoms at presentation rarely developed them subsequently; if they did, there were no abnormal signs. The data suggest that ophthalmological disorders may trigger idiopathic blepharospasm in a substantial proportion of cases predisposed to develop this condition.
对272例特发性眼睑痉挛患者进行了回顾性研究，以确定局部眼部疾病在其病情中的作用。大多数患者（57%）在疾病发作时出现症状，如眼睛干涩、有沙粒感、刺激感或畏光，提示眼睑或眼表疾病。272例患者中有170例在就诊时进行了详细的眼科检查；其中64%的患者有眼部症状，40%有可证实的眼表或眼睑病变。此类病变通常为双侧性、慢性且对局部治疗有抵抗性。这些患者在长时间的潜伏期（通常为数年）后出现眼睑痉挛。单侧病变为急性，通常对局部治疗反应良好，但通常在六个月内会发展为双侧眼睑痉挛。在所有272例患者中，就诊时无眼部症状的患者随后很少出现此类症状；即使出现，也没有异常体征。数据表明，在很大一部分易患此病的病例中，眼科疾病可能引发特发性眼睑痉挛。
