Département d'opthalmologie et d'oto-rhino-laryngologie-chirurgie cervico-faciale, Faculté de médecine, Université Laval, Québec, Quebec, Canada.
Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Québec, Quebec, Canada; and.
Retin Cases Brief Rep. 2022 Jul 1;16(4):482-485. doi: 10.1097/ICB.0000000000001013.
To report a case of nonleaking cystoid macular edema (CME) associated with pentosan polysulfate sodium (PPS)-induced pigmentary maculopathy.
Multimodal imaging, including optical coherence tomography, fundus photography, autofluorescence, and fluorescein angiography, was used to substantiate our diagnosis, further characterize the cystoid macular edema showed by our patient and to monitor the response to treatment.
A 59-year-old woman was referred for decreased visual acuity and bilateral macular edema. She had been treated for interstitial cystitis with PPS for 10 years. Multimodal imaging showed the characteristic features of PPS-induced pigmentary maculopathy. Moreover, fluorescein angiogram showed nonleaking cystoid macular edema in both eyes. She was treated successfully with intravitreal injections of bevacizumab.
To our knowledge, this report is the first to demonstrate that PPS-associated cystoid macular edema can be nonleaking on fluorescein angiography and responds well to intravitreal anti-vascular endothelial growth factor injections.
报告 1 例与聚戊烯糖硫酸钠（PPS）诱导的色素性视网膜炎相关的非渗漏性囊样黄斑水肿（CME）病例。
采用多模态成像，包括光相干断层扫描、眼底照相、自发荧光和荧光素血管造影，以证实我们的诊断，进一步描述我们患者的囊样黄斑水肿特征，并监测治疗反应。
一名 59 岁女性因视力下降和双眼黄斑水肿就诊。她因间质性膀胱炎已接受 PPS 治疗 10 年。多模态成像显示出 PPS 诱导的色素性视网膜炎的特征性表现。此外，荧光素血管造影显示双眼存在非渗漏性囊样黄斑水肿。她成功接受了玻璃体腔注射贝伐单抗治疗。
据我们所知，该报告首次表明 PPS 相关的囊样黄斑水肿在荧光素血管造影上可能是非渗漏性的，并对玻璃体腔抗血管内皮生长因子注射反应良好。
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