Reddy Vamsi, Grogan Dayton, Ahluwalia Meenakshi, Salles Évila Lopes, Ahluwalia Pankaj, Khodadadi Hesam, Alverson Katelyn, Nguyen Andy, Raju Srikrishnan P, Gaur Pankaj, Braun Molly, Vale Fernando L, Costigliola Vincenzo, Dhandapani Krishnan, Baban Babak, Vaibhav Kumar
Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA USA.
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.
EPMA J. 2020 Apr 15;11(2):217-250. doi: 10.1007/s13167-020-00203-4. eCollection 2020 Jun.
Cannabis-inspired medical products are garnering increasing attention from the scientific community, general public, and health policy makers. A plethora of scientific literature demonstrates intricate engagement of the endocannabinoid system with human immunology, psychology, developmental processes, neuronal plasticity, signal transduction, and metabolic regulation. Despite the therapeutic potential, the adverse psychoactive effects and historical stigma, cannabinoids have limited widespread clinical application. Therefore, it is plausible to weigh carefully the beneficial effects of cannabinoids against the potential adverse impacts for every individual. This is where the concept of "personalized medicine" as a promising approach for disease prediction and prevention may take into the account. The goal of this review is to provide an outline of the endocannabinoid system, including endocannabinoid metabolizing pathways, and will progress to a more in-depth discussion of the therapeutic interventions by endocannabinoids in various neurological disorders.
受大麻启发的医疗产品正日益受到科学界、普通大众和卫生政策制定者的关注。大量科学文献表明，内源性大麻素系统与人类免疫学、心理学、发育过程、神经元可塑性、信号转导和代谢调节有着复杂的相互作用。尽管大麻素具有治疗潜力，但由于其不良的精神活性作用和历史上的污名化，其临床广泛应用受到限制。因此，仔细权衡大麻素对每个个体的有益效果与潜在不利影响是合理的。这就是“个性化医疗”这一有前景的疾病预测和预防方法可能会考虑的地方。本综述的目的是概述内源性大麻素系统，包括内源性大麻素代谢途径，并将进一步深入讨论内源性大麻素在各种神经系统疾病中的治疗干预。
