Department of Pulmonary Medicine, SAMC and PGI, Indore, India.
Department of Pulmonary Medicine, MGM Medical College, Indore, India.
Indian J Tuberc. 2020 Apr;67(2):268-273. doi: 10.1016/j.ijtb.2019.09.001. Epub 2019 Sep 12.
Mortality in patients with pulmonary tuberculosis remains high, especially in those who develop acute respiratory distress syndrome (ARDS). We herein, report a case of 40 year old female, with ARDS due to severe pulmonary tuberculosis. She was admitted in the intensive care unit of a tertiary care centre. Owing to very poor ABG report, she was intubated and put on Mechanical ventilator support. Bronchoscopy was performed and BAL was extracted, which showed no growth. Further deterioration of gas exchange prompted the decision to put her on ECMO. During her stay on ECMO, she developed massive inta-alveolar hemorrhage following which repeated bronchoscopic interventions were done to remove blood clots. BAL extracted on day 4 and day 8 showed growth of A. baumannii and K. pneumoniae respectively. But BALGeneXpert on day 8 came out to be positive for Mycobacterium Tuberculosis and subsequently ATT was added to her treatment regimen. Her alveolar hemorrhage continued to worsen and subsequently ECMO was removed. After 12 days of hospitalization, she went on to develop bradycardia and could not be rescued. Though the patient's life was lost, this case provided many insights on the use of ECMO in the management of ARDS due to Pulmonary tuberculosis and it should be considered as one of the treatment options.
肺结核患者的死亡率仍然很高,特别是那些发展为急性呼吸窘迫综合征(ARDS)的患者。在此,我们报告了一例 40 岁女性因严重肺结核导致 ARDS 的病例。她被收入一家三级护理中心的重症监护病房。由于血气分析报告非常差,她被插管并接上了机械呼吸机支持。进行了支气管镜检查并提取了支气管肺泡灌洗液(BAL),但没有发现生长物。气体交换进一步恶化促使决定将她转用体外膜肺氧合(ECMO)。在 ECMO 治疗期间,她发生了大量肺泡内出血,随后进行了多次支气管镜介入以清除血块。第 4 天和第 8 天提取的 BAL 分别显示出鲍曼不动杆菌和肺炎克雷伯菌的生长。但第 8 天的 BALGeneXpert 检测结果呈结核分枝杆菌阳性,随后在她的治疗方案中加入了抗结核药物(ATT)。她的肺泡出血持续恶化,随后 ECMO 被移除。住院 12 天后,她出现心动过缓,无法抢救。尽管患者失去了生命,但该病例为 ECMO 在治疗肺结核引起的 ARDS 方面的应用提供了许多启示,应将其视为治疗选择之一。