Department of Orthopaedic Surgery, Columbia University Medical Center/Presbyterian Hospital, New York, NY, USA.
Department of Orthopaedic Surgery, Columbia University Medical Center/Presbyterian Hospital, New York, NY, USA.
J Shoulder Elbow Surg. 2020 Jul;29(7):1380-1386. doi: 10.1016/j.jse.2020.02.026.
Heterotopic ossification (HO) is a common complication of surgically treated elbow fractures that can inhibit range of motion and impair quality of life. Although there are many treatment methods for HO, there is a lack of consensus as to the best option. We hypothesized that contracture release combined with Botox injection would lead to improved functional outcome scores when compared with current treatment methods.
A retrospective review was conducted of patients who presented to a single surgeon with HO secondary to elbow fracture between 2005 and 2018. A total of 59 patients were identified who met inclusion criteria. Data were classified into 3 groups: contracture release (control - CR), Botox injection with CR (Botox + CR), and radiation therapy with CR (CR + RT). Range of motion measurements were obtained, including flexion, extension, pronation, and supination.
A total of 30 patients (30 of 59, 50.8%) received CR, 6 (6 of 59, 9.2%) were treated with CR + RT, and 23 (23 of 59, 40.0%) had CR + Botox. There was a significant difference between pre- and postoperative arc of motion for both CR + RT (P < .01) and CR + Botox (P < .01). In addition, there was a significant difference in pre- and postoperative extension for patients who received intraoperative Botox injections (P < .05). There was no significant difference between pre- and postoperative motion nor extension in the CR group.
Intraoperative Botox injection with CR is an effective method in the treatment of post-traumatic elbow stiffness caused by HO.
异位骨化(HO)是肘部骨折手术后的常见并发症,会限制关节活动度并降低生活质量。尽管有许多治疗 HO 的方法,但对于最佳治疗方案仍存在争议。我们假设与目前的治疗方法相比,挛缩松解联合肉毒毒素注射可改善功能预后评分。
对 2005 年至 2018 年间因肘部骨折而发生 HO 并由一位外科医生治疗的患者进行了回顾性研究。共确定了 59 名符合纳入标准的患者。将数据分为 3 组:挛缩松解(对照组-CR)、CR 联合肉毒毒素注射(Botox+CR)和 CR 联合放射治疗(CR+RT)。获得了包括屈曲、伸展、旋前和旋后在内的关节活动度测量值。
共有 30 名患者(59 名中的 30 名,50.8%)接受了 CR,6 名(59 名中的 6 名,9.2%)接受了 CR+RT,23 名(59 名中的 23 名,40.0%)接受了 CR+Botox。CR+RT(P<0.01)和 CR+Botox(P<0.01)的术前和术后运动弧均有显著差异。此外,接受术中肉毒毒素注射的患者的术后伸展度也有显著差异(P<0.05)。CR 组的术前和术后运动度以及伸展度均无显著差异。
CR 联合术中肉毒毒素注射是治疗由 HO 引起的创伤后肘部僵硬的有效方法。