Truth in science: experimental design and the legacy of John D Biggers, PhD., DSc.

The current article presents a brief historical perspective on Professor John D Biggers, PhD, DSc. who died on 7 April, 2018. His interests covered reproductive physiology, embryo culture, cryobiology, sperm preservation, statistics and experimental design, and the history and ethics of human reproductive biology. Emphasis is placed on John Biggers' approach to the development of media for the culture of mammalian preimplantation embryos and to correct several minor misconceptions that have arisen in recent years regarding some of his studies. Much can be learned from his detailed approach to scientific investigation and experimental design. His scientific accomplishments and seminal contributions are important, but the tapestry of his life and legacy continue to be woven through the many students, fellows, and collaborators with whom he worked with over many years. The present article builds on a previous conversation that Michael Summers and Catherine Racowsky had with John Biggers that was published in 2008 [1].